Name | 2,4-dichloro-5-nitropyrimidine |
Synonyms | 2,4-dichloro-5-nitropyrimidine 2,4-DICHLORO-5-NITROPYRIMIDINE 2,4-Dichloro-5-nitro-1,3-diazine Pyrimidine, 2,4-dichloro-5-nitro- 2,4- twochloro -5-nitropyriMidine |
CAS | 49845-33-2 |
EINECS | 629-447-5 |
InChI | InChI=1/C4HCl2N3O2/c5-3-2(9(10)11)1-7-4(6)8-3/h1H |
InChIKey | INUSQTPGSHFGHM-UHFFFAOYSA-N |
Molecular Formula | C4HCl2N3O2 |
Molar Mass | 193.98 |
Density | 2.0263 (rough estimate) |
Melting Point | 28-32°C |
Boling Point | 0.9°C0.5mm Hg |
Flash Point | >230°F |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 0.000428mmHg at 25°C |
Appearance | Liquid or Low Melting Solid |
Color | Clear yellow |
pKa | -6.02±0.29(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Sensitive | Moisture Sensitive |
Refractive Index | 1.6100 (estimate) |
Physical and Chemical Properties | Melting Point: 26 - 27 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
HS Code | 29335990 |
Hazard Note | Irritant/Moisture Sensitive/Keep under Argon |
Hazard Class | IRRITANT, LACHRYMATO |
introduction | 2,4-dichloro -5 nitropyrimidine is a light yellow crystal or liquid, melting point: 28-32 ℃, boiling point: 0.9 ℃/0.5mmHg, flash point: greater than 110 ℃, solid phase synthesis of diaminopurine intermediate, usually produced by rotary dryer. |
Application | 2, 4-dichloro-5 nitropyrimidine is a heterocyclic derivative that can be used as a pharmaceutical intermediate. |
synthesis method | 2, 4-dichloro-5-nitropyrimidine In the existing synthesis methods, hydrochloric acid or sulfoxide chloride or phosphorus oxychloride or phosphorus oxychloride are used for chlorination, but when hydrochloric acid or sulfoxide chloride is used for chlorination, the chlorination ability is low, the reaction is very small, and the yield is very low; when chlorination is directly chlorinated with phosphorus oxychloride, the reaction speed is very slow, there are many impurities and the efficiency is very low. |
Uses | Intermediates for solid phase synthesis of diaminopurine compounds. |